In the 2000, the Budweiser "Whassup?" guys made their commercial debut. The ad spot (in which a bunch of guys kept yelling "Whassup?" into their phones) was widely parodied in songs, comedy skits and other ads. Everyone and his grandmother began using that phrase.
Personally, I found the "Whassup?" craze annoying and stupid, so when this new version (above) showed up, my initial reaction was to skip it altogether. But I force myself to watch train wrecks on TV, so I forced myself to watch the video. And I'm so glad I did.
Finally, something I really can say "Whassup?" to, and really mean it.